Professor Eleanor Davies, Institute of Cardiovascular and Medical Sciences, University of Glasgow .
Telephone +44 141 330 2376.
Institution: University of Glasgow
Glasgow Team: Professor Eleanor Davies (Professor of Molecular Endocrinology), Dr Marie Freel (Consultant Endocrinologist), Dr Scott MacKenzie (Lecturer), Dr John McClure (Statistician)
Tasks in the project: Eleanor Davies is co-leader of WP2 and will contribute to WP4.
The main objective of WP2 is to perform genomic analyses in a discovery cohort using multiple individual platforms. Her team will contribute to obtaining circulating miRNA profiles in patients with Primary Aldosteronism and controls. The validity of the miRNA signature will be tested in a validation cohort in WP4.
Eleanor Davies is Professor of Molecular Endocrinology at the BHF Glasgow Cardiovascular Research Institute at the University of Glasgow (UK). She received her BSc (Hons) in Biochemistry from the University of Glasgow and her PhD from the University of Edinburgh. She spent 3 years as a post-doctoral research fellow at INSERM U36 in Paris.
At Glasgow, she leads a translational research group investigating the role of the mineralocorticoid aldosterone in cardiovascular disease, focusing on the regulation of its production by the adrenal gland and its role in hypertension. Her work has been funded by grants from the MRC, BHF, CSO and Hypertension Trust. It has been published in high profile journals and has been presented at several national and international meetings. She is co-director of the University MSc Cardiovascular Sciences programme and is the Institute Post-Graduate Director.
She is a member of the Society for Endocrinology, The Endocrine Society and the American Heart Association. She is a member of council for the Society for Endocrinology and is a member of their publications and nominations committee and co-lead of the Society’s adrenal/ cardiovascular Network. She serves as a reviewer for multiple national and international funding organisations and journals. She sits on the Chief Scientist Office committee for experimental and translational medicine and is the UK lead and member of an EU-COST ADMIRE network. She has served as an Editorial board member for Endocrinology and been Chairman of the International Aldosterone conference.
Robertson S, MacKenzie SM, Alvarez-Madrazo S, Diver LA, Lin J, Stewart PM, Fraser R, Connell JM, Davies E. MicroRNA-24 is a novel regulator of aldosterone and cortisol production in the human adrenal cortex. Hypertension. 2013 Sep;62(3):572-8.
Alvarez-Madrazo S, Mackenzie SM, Davies E, Fraser R, Lee WK, Brown M, Caulfield MJ, Dominiczak AF, Farrall M, Lathrop M, Hedner T, Melander O, Munroe PB, Samani N, Stewart PM, Wahlstrand B, Webster J, Palmer CN, Padmanabhan S, Connell JM. Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension. Hypertension. 2013 Jan;61(1):232-9.
Freel EM, Mark PB, Weir RA, McQuarrie EP, Allan K, Dargie HJ, McClure JD, Jardine AG, Davies E, Connell JM. Demonstration of blood pressure-independent noninfarct myocardial fibrosis in primary aldosteronism: a cardiac magnetic resonance imaging study. Circulation Cardiovasc Imaging. 2012 (6):740-7.
McManus F, Sands W, Diver L, MacKenzie SM, Fraser R, Davies E, Connell JM. APEX1 regulation of aldosterone synthase gene transcription is disrupted by a common polymorphism in humans. Circ Res. 2012 Jul 6;111(2):212-9.
Connell JM, MacKenzie SM, Freel EM, Fraser R, Davies E. A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function. Endocr Rev. 2008 Apr;29(2):133-54.