Sheerazed Boulkroun is INSERM Senior Researcher in team 14 « Genetic mechanisms of aldosterone related disorders » at the Paris Cardiovascular Research Center (PARCC), INSERM U970, Paris, France. She is working on the understanding on the mechanisms involved in the formation and development of aldosterone producing adenoma in primary aldosteronism. She is an expert in the field of aldosterone research, with expertise ranging from aldosterone biosynthesis to renal effects of the hormone.
She studied molecular and cellular biology at the university Pierre et Marie Curie in Paris (France). She has completed her PhD in Physiology and Physiopathology at the University Paris Diderot in Paris (France) in 2003. Her PhD was focused on the identification of early aldosterone induced genes in the rat cortical collecting duct. She identified especially NDRG2 as a new effector of aldosterone signaling in the kidney. After her PhD, she has done a first post-doc in the Pharmacology and Toxicology Department in Lausanne (Switzerland) where her research has been focused on the regulation of the epithelial sodium channel ENaC expression and trafficking by ubiquitylation/deubiquitylation mechanisms. She has done a second post-doc in the Pasteur Institute in Paris (France) where she has investigated the role of Mycolactone, a toxin produced by Mycobacterium Ulcerans, on T Lymphocytes induced anergy. In 2008, she finally joined the team of Maria Christina Zennaro, which is devoted to the study of the genetic mechanisms of aldosterone related disorders. She develops research axes on the physiological and pathophysiological development of the human adrenal. She now aims to use integrative whole-animal approaches to understand the mechanisms responsible for APA development.
She is member of the French COMETE network on adrenal tumors, of the European Network for the Study of Adrenal Tumors (ENS@T) and of the American Endocrine Society.