Available soon

Available soon

Available soon

EDUCATION AND POSTS HELD

CURRENT POSITIONS

PREVIOUS POSITIONS

FELLOWSHIPS AND AWARDS

MAJOR COLLABORATIONS (Selection)

Collaborations are in place with a number of ENSAT members and more specifically with the consortium of ENSAT-CANCER (Wiebke Arlt, Bruno Allolio, Martin Fassnacht, Jerôme Bertherat, Graeme Eisenhofer, Mercedes Robledo), which I coordinate since 2011. Pertaining to the proposed working program further important collaborations are in place with members of the German Conn registry (Martin Reincke, Marcus Quinkler, Holger Willenberg) and with the Helmholtz Centre in Munich for genetic investigation and mouse models (Tim Strom, Martin Hrabe de Angelis).

Martin Heinrich Reincke is the director of the Medizinische Klinik and Poliklinik IV, Ludwig-Maximilians University in Munich and Chair of the Department of Endocrinology and Diabetology. The Medizinische Klinik IV is part of Ludwig-Maximilians University, the leading institution in German academic medicine.

His research specialities include adrenal physiology and pathophysiology, endocrine hypertension, pituitary disease, mineralocorticoid and glucocorticoid action and stress research. Professor Reincke is heading a research team specifically exploring the prevalence and relevance of mineralocorticoid excess in resistant hypertension on the epidemiological, clinical, genetic and molecular level.

The research teams of his clinic have particular expertise in assay development and validation for endocrine disease, development of genetically manipulated animals as models for human adrenal disease.

Professor Reincke is a member of many national and international societies, including the Endocrine Society, European Society of Endocrinology and European Network of the study of adrenal tumors. He has served in the Executive Board of the German Endocrine Society and European Society of Endocrinology, is on the editorial board of several international journals, and has served as teaching dean of the faculty from 2006-2012.

Currently, he is president of the German Endocrine Society (2014-2017). He has published more than 290 Medline listed publications cited >6000 times, his h-index is 46.

Selected 5 publications from the last 5 years (out of 298; h-index: 46)

Reincke M, Sbiera S, Hayakawa A, Theodoropoulou M, Osswald A, Beuschlein F, Meitinger T, Mizuno-Yamasaki E, Kawaguchi K, Saeki Y, Tanaka K, Wieland T, Graf E, Saeger W, Ronchi CL, Allolio B, Buchfelder M, Strom TM, Fassnacht M, Komada M. Mutations in the deubiquitinase gene USP8 cause Cushing's disease. Nat Genet. 2015 Jan;47(1):31-8.

Di Dalmazi G, Kisker C, Calebiro D, Mannelli M, Canu L, Arnaldi G, Quinkler M, Rayes N, Tabarin A, Laure Jullié M, Mantero F, Rubin B, Waldmann J, Bartsch DK, Pasquali R, Lohse M, Allolio B, Fassnacht M, Beuschlein F, Reincke M. Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study. J Clin Endocrinol Metab. 2014 Oct;99(10):E2093-100. doi: 10.1210/jc.2014-2152. Epub 2014 Jul 24.

Beuschlein F, Fassnacht M, Assié G, Calebiro D, Stratakis CA, Osswald A, Ronchi CL, Wieland T, Sbiera S, Faucz FR, Schaak K, Schmittfull A, Schwarzmayr T, Barreau O, Vezzosi D, Rizk-Rabin M, Zabel U, Szarek E, Salpea P, Forlino A, Vetro A, Zuffardi O, Kisker C, Diener S, Meitinger T, Lohse MJ, Reincke M, Bertherat J, Strom TM, Allolio B. Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome. N Engl J Med. 2014 Mar 13;370(11):1019-28.

Beuschlein F, Boulkroun S, Osswald A, Wieland T, Nielsen HN, Lichtenauer UD, Penton D, Amar L, Fischer E, Walther A, Schack V, Tauber P, Schwarzmayr T, Diener S, Allolio B, Samson-Couterie B, Benecke A, Quinkler M, Fallo F, Plouin PF, Mantero F, Meitinger T, Mulatero P, Jeunemaitre X, Warth R, Vilsen B, Zennaro MC, Strom TM, Reincke M. Somatic ATP1A1 and ATP2B3 mutations leading to aldosterone producing adenomas and secondary hypertension. Nat Genet. 2013 Apr;45(4):440-4, 444e1-2

Reincke M, Fischer E, Gerum S, Merkle K, Schulz S, Pallauf A, Quinkler M, Hanslik G, Lang K, Hahner S, Allolio B, Meisinger C, Holle R, Beuschlein F, Bidlingmaier M, Endres S; German Conn's Registry-Else Kröner-Fresenius-Hyperaldosteronism Registry Observational study mortality in treated primary aldosteronism: the German Conn's registry. Hypertension. 2012 Sep;60(3):618-24.

Available soon

Graeme Eisenhofer received his PhD in 1983 from the University of Otago, New Zealand, with thesis work involving clinical research on autonomic and neuroendocrine systems. He then moved to the NIH where he carried out basic and clinical studies mapping the pathways of catecholamine metabolism. In 1988 he moved to the Baker Heart Research Institute (Melbourne, Australia), where he worked with Dr. Murray Esler on sympathetic nerve function in health and disease. He returned to the NIH in 1991 before taking up a Professorship at the University Hospital in Dresden, Germany. Together with Dr. Jacques Lenders, he developed measurements of plasma metanephrines for laboratory diagnosis of pheochromocytoma. He was also responsible for the first ever synthesis of ¹⁸F-fluorodopamine as a positron emission tomographic imaging agent for localizing catecholamine-producing tumors. At Dresden Prof. Eisenhofer heads the Division of Clinical Neurochemistry and is the Clinical Research Coordinator for the DFG-supported Dresden Adrenal Center (www.kfo252.de). Research is directed to studies of endocrine hypertension and involvement of the adrenal in pathophysiological processes. With 35 years of clinical research experience he has authored over 400 research articles, reviews and book chapters, most of which have been directed to autonomic- or adrenal-related disorders.

Available soon

John Connell, University of Dundee

John Connell is Vice Principal and Professor of Endocrinology at the University of Dundee and the Chair of NHS Tayside.

He trained in Medicine at the University of Glasgow (graduating with commendation in 1977) and his early clinical experience was gained in the West of Scotland. He has had a long-standing interest in the regulation of adrenal corticosteroids (Aldosterone and Cortisol) and in the role of these hormones in cardiovascular disease. In particular, his work focuses on the genes that control the late stages of synthesis of aldosterone and cortisol and how variation in these genes might predispose to cardiovascular risk.

Before taking up his present role, John was Dean of the School of Medicine at the University of Dundee (2009-2012) and Head of the College of Medicine, Dentistry and Nursing, as well as Vice Principal for Research (2012-2015).  During this period, he led the Medical School through a restructuring programme and a major refurbishment, to sustain its reputation among the very highest Medical Schools in the United Kingdom for the quality of its teaching, reputation of its clinical training and translational clinical science. He initiated the development of an Academic Health Sciences Partnership between the College of Medicine, Dentistry and Nursing and the NHS in Tayside that is designed to drive innovation in undergraduate and postgraduate education and training; quality improvement in healthcare and translational research. This partnership is now leading a strong portfolio of research, innovation and educational programmes.

John Connell is a Fellow of Academy of Medical Sciences, and a Fellow of the Royal Society of Edinburgh. He sits on the Finance Committee of the Academy of Medical Sciences; is Fellowship Secretary of the Royal Society of Edinburgh; Chair of the General Medical Council Education and Training Advisory Board; Chair of the Editorial Board of Clinical Endocrinology; Chair of Tenovus Tayside; and is the Vice Chair of the British Heart Foundation Programmes and Chairs Committee.

Professor Eleanor Davies, Institute of Cardiovascular and Medical Sciences, University of Glasgow .

Telephone +44 141 330 2376.

 Eleanor.Davies@glasgow.ac.uk

http://www.gla.ac.uk/researchinstitutes/icams/

Institution: University of Glasgow

Glasgow Team: Professor Eleanor Davies (Professor of Molecular Endocrinology), Dr Marie Freel (Consultant Endocrinologist), Dr Scott MacKenzie (Lecturer), Dr John McClure (Statistician)

Tasks in the project: Eleanor Davies is co-leader of WP2 and will contribute to WP4. 

The main objective of WP2 is to perform genomic analyses in a discovery cohort using multiple individual platforms. Her team will contribute to obtaining circulating miRNA profiles in patients with Primary Aldosteronism and controls.   The validity of the miRNA signature will be tested in a validation cohort in WP4.   

Biography:

Eleanor Davies is Professor of Molecular Endocrinology at the BHF Glasgow Cardiovascular Research Institute at the University of Glasgow (UK). She received her BSc (Hons) in Biochemistry from the University of Glasgow and her PhD from the University of Edinburgh.  She spent 3 years as a post-doctoral research fellow at INSERM U36 in Paris. 

At Glasgow, she leads a translational research group investigating the role of the mineralocorticoid aldosterone in cardiovascular disease, focusing on the regulation of its production by the adrenal gland and its role in hypertension.  Her work has been funded by grants from the MRC, BHF, CSO and Hypertension Trust.   It has been published in high profile journals and has been presented at several national and international meetings.   She is co-director of the University MSc Cardiovascular Sciences programme and is the Institute Post-Graduate Director.

 She is a member of the Society for Endocrinology, The Endocrine Society and the American Heart Association.  She is a member of council for the Society for Endocrinology and is a member of their publications and nominations committee and co-lead of the Society’s adrenal/ cardiovascular Network.   She serves as a reviewer for multiple national and international funding organisations and journals.  She sits on the Chief Scientist Office committee for experimental and translational medicine and is the UK lead and member of an EU-COST ADMIRE network. She has served as an Editorial board member for Endocrinology and been Chairman of the International Aldosterone conference. 

 Key publications

Robertson S, MacKenzie SM, Alvarez-Madrazo S, Diver LA, Lin J, Stewart PM, Fraser R, Connell JM, Davies E. MicroRNA-24 is a novel regulator of aldosterone and cortisol production in the human adrenal cortex. Hypertension. 2013 Sep;62(3):572-8.

Alvarez-Madrazo S, Mackenzie SM, Davies E, Fraser R, Lee WK, Brown M, Caulfield MJ, Dominiczak AF, Farrall M, Lathrop M, Hedner T, Melander O, Munroe PB, Samani N, Stewart PM, Wahlstrand B, Webster J, Palmer CN, Padmanabhan S, Connell JM. Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension. Hypertension. 2013 Jan;61(1):232-9.

Freel EM, Mark PB, Weir RA, McQuarrie EP, Allan K, Dargie HJ, McClure JD, Jardine AG, Davies E, Connell JM. Demonstration of blood pressure-independent noninfarct myocardial fibrosis in primary aldosteronism: a cardiac magnetic resonance imaging study. Circulation Cardiovasc Imaging. 2012 (6):740-7.

McManus F, Sands W, Diver L, MacKenzie SM, Fraser R, Davies E, Connell JM. APEX1 regulation of aldosterone synthase gene transcription is disrupted by a common polymorphism in humans. Circ Res. 2012 Jul 6;111(2):212-9.

Connell JM, MacKenzie SM, Freel EM, Fraser R, Davies E. A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function. Endocr Rev. 2008 Apr;29(2):133-54.

Wiebke Arlt undertook her under- and postgraduate training in Medicine and Endocrinology at the Universities of Cologne and Würzburg, Germany. This was followed by postdoctoral training at the University of California at San Francisco, funded by the German Research Council (DFG).

After her return to Germany she joined the University of Birmingham in 2002, funded by a DFG Heisenberg Senior Fellowship. In 2004 she was awarded an MRC Senior Clinical Fellowship, followed by a personal chair in 2006 and the William Withering Chair of Medicine in 2014.

Her research has unraveled the genetic and functional basis of several monogenic disorders affecting androgen synthesis and metabolism.She leads a multi-disciplinary research comprising clinician scientists, molecular biologists, biochemists and computer scientist, focussing on the exploration of the steroid metabolome and its impact on human disease.

Wiebke has led the Centre for Endocrinology, Diabetes and Metabolism (CEDAM) since its creation in 2008 and now serves as the founding Director of the Institute of Metabolism and Systems Research (IMSR) at Birmingham. Her multiple national and international awards include the Society for Endocrinology UK Medal (2009) and Clinical Endocrinology Trust Lecture (2015), the EJE Prize (2009) and Clinical Endocrinology Trust Medal (2015) of the European Society of Endocrinology, and the Ernst Oppenheimer Award 2010 of the Endocrine Society USA.

Dr Emily Jefferson joined the University of Dundee in 2012 and is the Director of the Health Informatics Centre (HIC). Emily read Biochemistry at the University of St Andrews before moving to attain a PhD in the more computational field of Bioinformatics at the University of Dundee. After a post-doc in Bioinformatics, Emily left academia to work in the banking sector for a large software company. She was promoted to Project Director, managing the delivery and development of multi-million pound software systems to several International Banks. Emily then took a career break to solo cycle from New Zealand to the UK over 1 year.

Emily wishes to combine an understanding of biological research and academia with commercial IT Project Management and Development experience and apply these skills to the field of Health Informatics.

Emily is co-director of Farr@Dundee and also has responsibility for the overall management, technical direction and leadership for a team of software developers and data analysts within HIC.

Henri Timmers MD, PhD

Dept. of internal medicine, section of Endocrinology (471)

Radboud University Medical Centre

PO Box 9101, 6500 HB Nijmegen, The Netherlands

Tel: +31 243614599

Fax: +31 243618809

Email: henri.timmers@radboudumc.nl

Positions: Clinical endocrinologist and steering committee member of the European Network for the Study of Adrenal Tumors www.ensat.org  and the international  Pheochromocytoma and Paraganglioma Research Support Organization www.pressor.org

Principal clinical and scientific focus: adrenal diseases, in particular pheochromocytoma and paraganglioma

Tasks within ENSAT-HT consortium: Participation in WP3 (metabolomic profiling by nuclear magnetic resonance spectroscopy) and WP5 (clinical trial).

Professor Richard O. Sinnott is the Director of eResearch at the University of Melbourne and Chair of Applied Computing Systems. In these roles he is responsible for all aspects of eResearch (research-oriented IT development) at the University. He has been lead software engineer/architect on an extensive portfolio of national and international projects, with specific focus on those research domains requiring finer-grained access control (security). Within ENSAT-HT Richard is the technical lead for WP1 and providing the underlying data systems and security-oriented IT infrastructure. This leverages the existing ENSAT-CANCER systems developed by Richard’s team (now used globally by - at present - 76 cancer centres).

Richard was formerly the Technical Director of the UK National e-Science Centre; Director of e-Science at the University of Glasgow; Deputy Director (Technical) for the Bioinformatics Research Centre also at the University of Glasgow, and for a while the Technical Director of the National Centre for e-Social Science. He has a PhD in Computing Science; an MSc in Software Engineering and a BSc in Theoretical Physics. He has over 250 peer-reviewed publications across a range of computing and application-specific domains.

Example Publications

1. Därr, C. Pamporak, M. Peitzsch, K. Miehle, A. Prejbisz, D. Weismann, F. Beuschlein, R.O. Sinnott, S. Bornstein, H. Neumann, A. Januszewicz, J. Lenders, G. Eisenhofer, Biochemical diagnosis of phaeochromocytoma using plasma free normetanephrine, metanephrine and methoxytyramine: Importance of supine sampling under fasting conditions, Journal of Clinical Endocrinology, 2013, doi: 10.1111/cen.12327.
2. Penno, J. Couper, M. Craig, P. Colman, W. Rawlinson, A. Cotterill, T. Jones, L. Harrison, P. Baghurst, S. Barry, F. Cameron, J. Dodd, C. Duran, J. Forbes, M. Makrides, G. Morahan, K. Nelson, A. Nankervis, R.O. Sinnott, J. Wentworth, Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes, BMC Pediatrics, 13:124, doi:10.1186/1471-2431-13-124.
3. Kolesinska, S.F. Ahmed, M. Niedziela, J. Bryce, M. Rodie, J. Jiang, R.O. Sinnott, I. Hughes, F. Darendeliler, O. Hiort, Y. van der Zwan, M. Cools, T. Guran, P.M. Holterhus, S. Bertelloni, L. Lisa, W. Arlt, N. Krone, M. Ellaithi, A. Balsamo, I. Mazen, A. Nordenstrom, K. Lachlan, M. Alkhawari, P. Chatelain, N. Weintrob, Changes Over Time In Sex Assignment For Disorders Of Sex Development, Journal of Paediatrics, May 2014.
4. Kanwal, A. Lonie, R.O. Sinnott, C. Anderson, Challenges of Large-scale Biomedical Workflows on the Cloud – A Case Study on the Need for Reproducibility of Results, 28^th IEEE International Conference on Computer Based Medical Systems, Sao Paolo, Brazil, June 2015.
5. Wise, C. Friedrich, S. Nepal, S. Chen, R.O. Sinnott, CloudDocs: Secure Scalable Document Sharing on Public Clouds, IEEE Cloud Conference 2015, New York, USA, July 2015.

Contact Details

Prof. Richard O. Sinnott

Director,  eResearch

322 Doug McDonell Building, University of Melbourne

Tel: +61-(0)3-9035-4531 Fax: -8700 Mob: +61-(0)435-964-844

Email: rsinnott@unimelb.edu.au

 Dr Jaap Deinum, MD PhD (b. 1961)

 1979-1980              Liberal arts propaedeutics at Free Academy, Driebergen, NL

• Medical School of Erasmus University, Rotterdam, Netherlands
• Social service (conscientious objector to military service), Univ. Hospital Dijkzigt (now: Erasmus MC) Rotterdam, NL
• Training as an internist Univ. Hospital Dijkzigt Rotterdam, supervisor Prof. Dr M.A.D.H. Schalekamp

1994 - Postdoc at INSERM U. 367, Paris, head Dr. F. Alhenc-Gelas

1995-2002 - Member of staff, department of Medicine, Erasmus Medical Center Rotterdam

1999 - PhD thesis ‘Structure and regulation of prorenin’

2002-now  -  Senior staff member, department of Medicine, University Medical Center Nijmegen St. Radboud

2003 - registration as Specialist in Vascular Medicine and as European Hypertension Specialist, associate professor

2012 - head of ESH Hypertension Excellence Center Radboud UMC

-Member of European Society of Hypertension and European Council for cardiovascular research and various national and international associations in the fields of hypertension, vascular medicine/biology, endocrinology, and  nephrology. Co-founder of the 'Internistisch Vasculair Genootschap’, Current president of the Dutch Society of Hypertension.

-Research interests: -genetics of hypertension, genomic screens, genetic determinants of sodium transport in renal tubules

-treatment strategies in primary hypertension

-diagnostic strategies in secondary hypertension, in particular endocrine hypertension

-personalized medicine

Joyce Koffeman, MSc.

Dept. of Internal Medicine, section of Vascular Medicine and Endocrinology (481)

Radboud University Medical Centre

PO Box 9101, 6500 HB Nijmegen, The Netherlands

Tel: +31 243618819

Fax: +31 243635126

Email: joyce.koffeman-smeltink@radboudumc.nl

 Positions: 9 years experience in Clinical trials as CRA, Senior Study Nurse and Research Coordinator, within Radboud University Medical Centre as well as the pharmacy. Conducting and coordinating clinical trials according to ICH-GCP guidelines and (European) laws and regulations. Phase I, II, II and IV in different areas:  geriatrics, HIV, Food supplements, hypertension, MS, surgery, oncology, malaria, drug eluting stents, allergology and cannabinoids. 

Tasks within ENSAT-HT consortium: coordinating role for Radboud University Medical Centre for WP3, WP4 and WP5.

Anthony Stell, Clinical Informatics Developer

University of Melbourne

Anthony Stell is a clinical informatics developer in the eResearch group at the University of Melbourne. In this role he is responsible for the project management and technical development of several advanced registries supporting clinical research in various domains such as adrenal cancer, spinal trauma and traumatic brain injury. He is the senior software developer for the ENSAT registry, which is a unique, well-used (with 76 active centers), security-focused resource for adrenal cancer, with advanced features to support statistical and bio-banking analyses for a diverse set of studies. Within ENSAT-HT Anthony is the senior technical developer for WP1 and will provide technical support and assistance for the underlying IT infrastructure.

Anthony worked formerly as a Grid Engineer at the UK National e-Science Centre at the University of Glasgow where he developed distributed, real-time clinical systems to support brain-injury studies in Europe (the Avert-IT project) and epidemiological trials in the UK (the VOTES project). During this time he also served as a member of the Grid Engineering Task Force (Grid ETF, UK).

He is currently in the final year of a PhD in Clinical Physics at the University of Glasgow studying clinical variation and guideline adherence in traumatic brain injury through neurological ICU data analysis. He has an MSc in Information Technology from the University of Glasgow, an MPhys in Astrophysics from the University of Edinburgh, and is a Chartered Member of the British Computing Society (CITP MBCS). He has over 40 peer-reviewed publications across a range of computing and application-specific domains.

Example Publications

1. Eisenhofer G, Brown S, Peitzsch M, Pelzel D, Lattke P, Glöckner S, Stell A, Prejbisz A, Fassnacht M, Beuschlein F, Januszewicz A, Siegert G, Reichmann H - "Levodopa therapy in Parkinson’s disease: influence on liquid chromatographic tandem mass spectrometric-based measurements of plasma and urinary normetanephrine, metanephrine and methoxytyramine", Annals of Clinical Biochemistry, 2014 Jan; 51 (Pt 1):38-46

2. Felix Beuschlein, Jens Weigel, Wolfgang Saeger, Matthias Kroiss, Vanessa Wild, Fulvia Daffara, Rosella Libé, Arianna Ardito, Abir Al Ghuzlan, Marcus Quinkler, Andrea Oßwald, Cristina L. Ronchi, Ronald de Krijger, Richard A. Feelders, Jens Waldmann, Holger S. Willenberg, Timo Deutschbein, Anthony Stell, Martin Reincke, Mauro Papotti, Eric Baudin, Frédérique Tissier, Harm R. Haak, Paola Loli, Massimo Terzolo, Bruno Allolio, Hans-Helge Müller, and Martin Fassnacht - "Major Prognostic Role of Ki67 in Localized Adrenocortical Carcinoma After Complete Resection", The Journal of Clinical Endocrinology & Metabolism 2015, 100:3, 841-849

3. Anthony Stell, Richard Sinnott, Jipu Jiang, Rob Donald, Iain Chambers, Giuseppe Citerio, Per Enblad, Barbara Gregson, Tim Howells, Karl Kiening, Pelle Nilsson, Arminas Ragauskas, Juan Sahuquillo, Ian Piper – “Federating distributed clinical data for the prediction of adverse hypotensive events”, Philosophical Transactions of the Royal Society of London A, 2009, vol 367 (1898), pp 2679-2690

Contact Details

Anthony Stell

Clinical Informatics Developer

324 Doug McDonell Building, University of Melbourne

Tel: +61-(0)3-9035-3755 Mob: +61-(0)478-313-748

Email: astell@unimelb.edu.au

Catherine joined Inserm-Transfert in 2005. She graduated from the Ecole Normal Superieure, Catherine received a Ph.D. in Molecular Virology at the University René Diderot in 1996. She completed her studies mainly in the private sector (pre-doctoral study at Loreal and PhD thesis at Genset). After her thesis, she continued her research on cardiovascular disease in biotechnology companies. She also won the Aventis Foundation for the creation of the company Helios Biosciences and helped set up within the engineering school ESIEA a teaching methodology in bioinformatics and life sciences. She is a regular expert at the European Commission for the People program. Thanks to her job training and experience as project leader in biotech, Catherine has experience with managing international research projects and multidisciplinary. She is fluently bilingual through daily practice of English in their professional activities.

As senior manager of the European project, Catherine Clusel acquired within 7 years of Inserm-Transfert extensive experience installing and managing European projects (FP6 and FP7) and transatlantic (Fondation Leducq) in the field of metabolic and cardiovascular diseases. She participated in the assembly and / or management projects such as: EVGN (FP6-NoE coordinated by Inserm), Florinash (FP7-medium-scale coordinated by INSERM) and MetaCARDIS (FP7-wide scale coordinated by INSERM). Catherine has a unique experience on the installation and management of transatlantic alliances Foundation Leducq (CAPTAA; cycAMP, MITRAL).

Silvia Monticone earned her MD in 2007 from University of Torino (Italy) and in 2013 she completed a residency in Internal Medicine at the same university.

In 2011, she spent one year as research fellow at Georgia Health Sciences University in the Department of Physiology, where she started a successful collaboration with the laboratory directed by Prof. WE Rainey. She is currently research scientist in Internal Medicine at the University of Torino, Italy; she is also member of the Italian Society of Hypertension since 2008 and in 2012 she won the Italian Hypertension Society fellowship.

Main publications:

- Monticone S, Satoh F, Giacchetti G, Viola A, Morimoto R, Kudo M, Iwakura Y, Ono Y, Turchi F, Paci E, Veglio F, Boscaro M, Rainey W, Ito S, Mulatero P. Effect of adrenocorticotropic hormone stimulation during adrenal vein sampling in primary aldosteronism. Hypertension. 2012;59:840-6.

- Monticone S, Hattangady NG, Nishimoto K, Mantero F, Rubin B, Cicala MV, Pezzani R, Auchus RJ, Ghayee HK, Shibata H, Kurihara I, Williams TA, Giri JG, Bollag RJ, Edwards MA, Isales CM, Rainey WE. Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells. J Clin Endocrinol Metab. 2012;97:E1567-72.

- Monticone S, Hattangady NG, Penton D, Isales CM, Edwards MA, Williams TA, Sterner C, Warth R, Mulatero P, Rainey WE. A Novel Y152C KCNJ5 Mutation Responsible for Familial Hyperaldosteronism Type III. J Clin Endocrinol Metab. 2013;98:E1861-5.

- Monticone S, Satoh F, Viola A, Fischer E, Vonend O, Bernini G, Lucatello B, Quinkler M, Ronconi V, Morimoto R, Kudo M, Degenhart C, Gao X, Carrara D, Willenberg HS, Rossato D, Mengozzi G, Riester A, Paci E, Iwakura Y, Burrello J, Maccario M, Giacchetti G, Veglio F, Ito S, Reincke M, Mulatero P. Aldosterone Suppression on Contralateral Adrenal During Adrenal Vein Sampling does not Predict Blood Pressure Response After Adrenalectomy. J Clin Endocrinol Metab. 2014;99: 4158-66.

- Monticone S, Viola A, Rossato D, Veglio F, Reincke M, Gomez-Sanchez C, Mulatero P. Adrenal vein sampling in primary aldosteronism: towards a standardised protocol. Lancet Diabetes Endocrinol. 2015;3:296-303.

Full list of publications is available at the link http://www.ncbi.nlm.nih.gov/pubmed/?term=monticone+s

Tasks in the project: Franco Rabbia is participant from the UNITO group involved in WP4-5. 

WP4-5: Contribution: - Recruitment of referred hypertension patients for the multicentre screening of established omics biomarkers to identify patients with overt endocrine hypertension, with subclinical forms and patients clustering into a specific endocrine group.

- Assessment of the validity of screening for omics biomarkers in hypertension patients to establish a stratified health promotion programme in hypertensive subjects.

Biography:

MD 25/11/1960 Turin

Graduation in Medicine and surgery (1986)

Clinical Fellow in Internal Medicine University of Turin( 1987-1992) (prof L. Chiandussi),)

From 1989 to 2002 senior house officier Division of Internal Medicine, Hypertension Unit (Director Prof. L. Chiandussi). From 2003 to now senior Registrar Division of Internal Medicine, Hypertension Unit (Director Prof. F. Veglio) Azienda. Ospedaliera Città della Salute e della Scienza- University of Turin.

Awards and Honors: European Society of Hypertension Specialist since 2001

Member: European Society of Hypertension, Italian Society of Hypertension

Teacher: degree course of Dietician University of Turin

Referee: BMJ, Preventive Medicine, Pediatrics, Circulation, International journal of Obesity

Main publications:

- Covella M, Milan A, Totaro S, Cuspidi C, Re A, Rabbia F, Veglio F. Echocardiographic aortic root dilatation in hypertensive patients: a systematic review and meta-analysis. J Hypertens. 2014;32:1928-35

-Totaro S, Rabbia F, Testa E, Covella M, Berra E, Fulcheri C, Mulatero P, Veglio F. Appropriateness of referral to a European society of hypertension center of excellence. J Clin Hypertens (Greenwich). 2012;14:729-30.

-Rabbia F, Rabbone I, Totaro S, Testa E, Covella M, Berra E, Bertello MC, Gioia E, Cerutti F, Veglio F. Evaluation of blood pressure/height ratio as an index to simplify diagnostic criteria of hypertension in Caucasian adolescents. J Hum Hypertens. 2011;25:623-4.

-Veglio F, Paglieri C, Rabbia F, Bisbocci D, Bergui M, Cerrato P. Hypertension and cerebrovascular damage. Atherosclerosis. 2009;205:331-41.

-Leotta G, Rabbia F, Canadè A, Testa E, Papotti G, Mulatero P, Veglio F. Characteristics of the patients referred to a Hypertension Unit between 1989 and 2003. J Hum Hypertens. 2008;22:119-21

Institution: UNITO. Contact: franco.veglio@unito.it

Tasks in the project: Franco Veglio is participant from the UNITO group involved in WP4-5. 

WP4-5: Contribution: see Franco Rabbia

Biography: Franco Veglio, MD, is Full Professor of Internal Medicine at the University of Turin, Italy, Head of Medical Sciences Department; Director of Internal Medicine and Hypertension Division; European Specialist in Clinical Hypertension, member of the European Society of Hypertension.. Main research topics:clinical studies on essential and endocrine hypertension; physiopathological studies on in the mechanism of resistant arterial hypertension. HI 41, IF ~ 950, i-10 index 126, total citations 6322

Main publications:

-Covella M, Milan A, Totaro S, Cuspidi C, Re A, Rabbia F, Veglio F. Echocardiographic aortic root dilatation in hypertensive patients: a systematic review and meta-analysis. J Hypertens. 2014; 32:1928-35

-Milan A, Puglisi E, Ferrari L, Bruno G, Losano I, Veglio F. Arterial hypertension and cancer. Int J Cancer. 2014;134:2269-77

-Milan A, Avenatti E, Tosello F, Iannaccone A, Leone D, Magnino C, Veglio F. Aortic root dilatation in essential hypertension: prevalence according to new reference values. J Hypertens. 2013;31:1189-95.

- Veglio F, Puglisi E, Milan A, Mulatero P. Combinations of renin-angiotensin-aldosterone system antagonists: true advantages? Curr Pharm Des. 2012;18:952-7.

-Grosso A, Cheung N, Veglio F, Wong TY. Similarities and differences in early retinal phenotypes in hypertension and diabetes. J Hypertens. 2011;29:1667-75

Institution: UNITO. Contact: jacopo.burrello@gmail.com

Tasks in the project: Jacopo Burrello is participant from the UNITO group involved in WP4-5. 

WP4-5: Contribution: see Franco Rabbia

Biography:

Jacopo Burrello, MD, is research fellow at the Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Turin, Italy. He is also member of the Italian Society of Hypertension.

Main publications:

- Mulatero P, Monticone S, Bertello C, Viola A, Tizzani D, Iannaccone D, Crudo V, Burrello J, Milan A, Rabbia F, Veglio F. Long-Term Cardio- and Cerebrovascular Events in Patients With Primary Aldosteronism. J Clin Endocrinol Metab 2013; 98: 4826-4833.

- Williams TA, Monticone S, Vivien R, Burrello J, Buffolo F, Castellano I, Beuschlein F, Reincke M, Lucatello B, Fallo F, Maccario M, Veglio F, Mulatero P, et al. Somatic ATP1A1, ATP2B3, and KCNJ5 Mutations in Aldosterone-Producing Adenomas. Hypertension 2013; 63(1):188-195.

- Monticone S, Satoh F, Viola A, Lucatello B, Burrello J, Maccario M, Veglio F, Reincke M, Mulatero P et al. Aldosterone Suppression on Contralateral Adrenal During Adrenal Vein Sampling does not Predict Blood Pressure Response After Adrenalectomy. J Clin Endocrinol Metab 2014; 99(11):4158-66.

- Grillo A, Bernardi S, Rebellato A, Fabris B, Bardelli M, Burrello J, Rabbia F, Veglio F, Fallo F, Carretta R. Ambulatory Blood Pressure Monitoring-Derived Short-Term Blood Pressure Variability in Primary Aldosteronism. J of Clin Hyperten 2015; (Epub ahead of print).

- Williams TA, Dietz A, Theodoropoulou M, Riester A, Fischer E, Burrello J, Treitl M, Geyer L, Veglio F, Bidlingmaier M, Schopohl J, Beuschlein F, Mulatero P, Reincke M. Co-existing prolactinoma and primary aldosteronism - is there a pathophysiological link? J Clin Endocrinol Metab 2015; (Epub ahead of print);

Full list of publications is available at the link

http://www.ncbi.nlm.nih.gov/pubmed/?term=burrello+j