Maria-Christina Zennaro is INSERM Research Director, head of team 14 “Genetic mechanisms of aldosterone related disorders” at the Paris Cardiovascular Research Center and associated investigator at the Genetics Department of the European Hospital Georges Pompidou in Paris (France).
She received her MD and board certification in Endocrinology at the University of Padova (Italy) and completed her PhD in Molecular Endocrinology at the University Pierre et Marie Curie in Paris (France). Her research team has developed a genome-wide strategy to explore the genetics and genomics of pseudohypoaldosteronism type 1 and primary aldosteronism, in order to generate knowledge translatable to patient’s care. She is principal investigator of the PHA1.NET network at the laboratory of genetics at HEGP, which is the French referral center for the genetic diagnosis of the disease. She is coordinator of an ANR-DFG funded French-German research network on the genetics of primary aldosteronism and coordinator of the EU H2020 funded program ENS@T-HT. Her team has recently been appointed by the Fondation pour la recherché médicale as FRM Team.
Maria-Christina Zennaro has been awarded for her work by the Italian Societies of Internal Medicine, Hypertension, Endocrinology, the French Society of Nephrology and the International Aldosterone Conference. She is head of the APA working group of the European Network for the Study of Adrenal Tumors (ENS@T), president of the European Section of Aldosterone council (ESAC)-France, member of the Executive Committee of the International Aldosterone Conference, working group leader of the European COST action ADMIRE and member of the European Society of Hypertension - Centre of Excellence for Hypertension at HEGP-Paris. She has been invited as 15th Richard Underwood Memorial Visiting Professor at the University of Harvard in 2014.
She serves a reviewer for multiple national and international funding organizations and journals and is member of the Editorial Board of the journal Endocrinology.
Anne-Paule Gimenez-Roqueplo (MD, specialized in Endocrinology, PhD) is Full Professor in the Department of Genetics (Assistance Publique-Hôpitaux de Paris; Hôpital Européen Georges Pompidou) and at Paris Descartes University. She is the leader of an academic research team entitled “Pheochromocytomas and paragangliomas (PCC/PGL), from genetics to molecular targeted therapies” within the INSERM Unit 970 at the Paris Cardiovascular Research Center at HEGP (PARCC@HEGP, Paris, France), which develops a basic, translational and clinical research project dedicated to PCC/PGL
Her group established the genetic testing recommendations for patients with PCC/PGL, demonstrated that the identification of a germline SDHB mutation is the first high risk factor of malignancy and of poor prognosis, showed that SDHx-related PCC/PGL are characterized by a stimulation of the hypoxia-angiogenesis pathway and by a hypermethylator phenotype, and published in 2015 the first integrated genomic analysis of a large series of PCC/PGL collected by the COMETE network. Her group develops an integrative genomic approach and different animal and cellular experimental models of malignant PCC/PGL. Her researches are supported by ANR (National Research Agency), the European Union (FP7 & H2020), INCa (National Cancer Institute) and the Ligue Nationale contre le Cancer (National League Against Cancer, ‘Tumor Identity Cards (CIT)’ Programme).
She is the past chairman of the Pheochromocytoma-Paraganglioma Research Support Organization (PRESSOR), the head of the Pheochromocytoma working group of the European Network for the Study of Adrenal Tumors (ENS@T) and member of the ENS@T steering committee. She coordinates the COMETE network and the French registry for SDH-related paraganglioma (PGL.R).
- Letouzé E, Martinelli C, Loriot C, Burnichon N, Abermil N, Ottolenghi C, Janin M, Menara M, Nguyen AT, Benit P, Buffet A, Marcaillou C, Bertherat J, Amar L, Rustin P, De Reyniès A, Gimenez-Roqueplo AP, Favier J. SDH mutations establish a hypermethylator phenotype in paraganglioma. Cancer Cell. 2013 Jun 10;23(6):739-52.
- Castro-Vega LJ, Buffet A, De Cubas AA, Cascón A, Menara M, Khalifa E, Amar L, Azriel S, Bourdeau I, Chabre O, Currás-Freixes M, Franco-Vidal V, Guillaud-Bataille M, Simian C, Morin A, Letón R, Gómez-Graña A, Pollard PJ, Rustin P, Robledo M, Favier J, Gimenez-Roqueplo AP. Germline mutations in FH confer predisposition to malignant pheochromocytomas and paragangliomas. Hum Mol Genet. 2014 May 1;23(9):2440-6.
- Castro-Vega LJ, Letouzé E, Burnichon N, Buffet A, Disderot PH, Khalifa E, Loriot C, Elarouci N, Morin A, Menara M, Lepoutre-Lussey C, Badoual C, Sibony M, Dousset B, Libé R, Zinzindohoue F, Plouin PF, Bertherat J, Amar L, de Reyniès A, Favier J, Gimenez-Roqueplo AP. Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas. Nat Commun. 2015 Jan 27;6:6044.
- Favier J, Amar L, Gimenez-Roqueplo AP. Paraganglioma and phaeochromocytoma: from genetics to personalized medicine. Nat Rev Endocrinol. 2015 Feb;11(2):101-11.
- Castro-Vega LJ, Lepoutre-Lussey C, Gimenez-Roqueplo AP, Favier J. Rethinking pheochromocytomas and paragangliomas from a genomic perspective. 2015 Jun 1.
Paris Cardiovascular Research Center, PARCC@HEGP,
56 rue Leblanc, Paris, France.
Tel: (33) 153 988 014; Fax: (33) 153 987 952;
Genetics Department, Hôpital européen Georges Pompidou
20-40 rue Leblanc, Paris, France
Tel: (33) 156 093 878; Fax: (33) 156 093 884
Sheerazed Boulkroun is INSERM Senior Researcher in team 14 « Genetic mechanisms of aldosterone related disorders » at the Paris Cardiovascular Research Center (PARCC), INSERM U970, Paris, France. She is working on the understanding on the mechanisms involved in the formation and development of aldosterone producing adenoma in primary aldosteronism. She is an expert in the field of aldosterone research, with expertise ranging from aldosterone biosynthesis to renal effects of the hormone.
She studied molecular and cellular biology at the university Pierre et Marie Curie in Paris (France). She has completed her PhD in Physiology and Physiopathology at the University Paris Diderot in Paris (France) in 2003. Her PhD was focused on the identification of early aldosterone induced genes in the rat cortical collecting duct. She identified especially NDRG2 as a new effector of aldosterone signaling in the kidney. After her PhD, she has done a first post-doc in the Pharmacology and Toxicology Department in Lausanne (Switzerland) where her research has been focused on the regulation of the epithelial sodium channel ENaC expression and trafficking by ubiquitylation/deubiquitylation mechanisms. She has done a second post-doc in the Pasteur Institute in Paris (France) where she has investigated the role of Mycolactone, a toxin produced by Mycobacterium Ulcerans, on T Lymphocytes induced anergy. In 2008, she finally joined the team of Maria Christina Zennaro, which is devoted to the study of the genetic mechanisms of aldosterone related disorders. She develops research axes on the physiological and pathophysiological development of the human adrenal. She now aims to use integrative whole-animal approaches to understand the mechanisms responsible for APA development.
She is member of the French COMETE network on adrenal tumors, of the European Network for the Study of Adrenal Tumors (ENS@T) and of the American Endocrine Society.
Fabio Fernandes RosaINSERM
Fabio Fernandes-Rosa is associated researcher of team 14 “Genetic mechanisms of aldosterone related disorders” at the Paris Cardiovascular Research Center.
He received his MD at the Federal University of Triangulo Mineiro (Brazil) and board certification in Pediatrics and Pediatric Endocrinology, as well as his Master Degree and PhD, at the School of Medicine of Ribeirao Preto (University of Sao Paulo, Brazil). He is a former attending physician at the Pediatric Endocrinology Service of the University Hospital of the School of Medicine of Ribeirao Preto (University of Sao Paulo, Brazil).
His research field comprises Endocrinology and Pediatric Endocrinology subjects, in particular translational research in aldosterone related disorders as pseudohypoaldosteronism type 1 and primary aldosteronism. His actual project concerns genome-wide strategy to explore the genetics and genomics of primary aldosteronism, in order to generate knowledge translatable to patient’s care. Fabio Fernandes-Rosa has been awarded for her work by the Brazilian Society of Endocrinology and Metabolism and the Capes Foundation (Brazil). He is member of the Endocrine Society, Brazilian Society of Endocrinology and Metabolism and the European Network for the Study of Adrenal Tumors (Ens@T), and serves as a reviewer for different international indexed scientific journals.
Casper Kornbech Larsen is a postdoc in team 14 “Genetic mechanisms of aldosterone related disorders” at the Paris Cardiovascular Research Center. He is currently working on developing methods to isolate DNA and RNA from circulating extracellular vesicles for use in detection of primary aldosteronism
He has studied biology at Aarhus University (Denmark) and received his Master Degree in 2011 and his PhD in 2015 from the Institute of Biomedicine at Aarhus University. The topic of his Master project was to explain why erythrocytes from ball pythons (python regius) are resistant to haemolysis by the poreforming toxin α-hemolysin from E. coli. In his PhD project, he studied the effect of ablation of the KCNMB2gene on renal and colonic potassium excretion in a mouse model. He joined the team of Maria-Christina Zennaro in April 2016.
EDUCATION AND POSTS HELD
Attending Physician / Consultant
Completion of residency in Internal Medicine/Endocrinology (University of Freiburg)
Postdoctoral fellow at the University of Michigan, Ann Arbor
Residency in Internal Medicine/Endocrinology at the Dept. of Internal Medicine, Endocrinology Division, University of Freiburg, Germany
Internship at the Dept. of Internal Medicine, University of Würzburg
Doctoral degree (Dr. med.) by the Faculty of Medicine, University of Würzburg
Medical School, University of Würzburg, Germany
Head of Endocrine Outpatient Clinic
Head of Endocrine Research, University of Munich (W2 Professorship)
Provisional Head of Division for Endocrinology and Diabetology, University of Freiburg
FELLOWSHIPS AND AWARDS
Rolf-Becker Award 2013 for the best publication at the LMU medical faculty
European Journal of Endocrinology Prize 2013 for significant contribution to the advancement of knowledge in the field of endocrinology (prize money € 10,000,- ; awarded annually to a European endocrinologist under the age of 45 years)
Merck Senior Fellow Award awarded by the Endocrine Society
Junior-Research-Group-Leader (Adult Stem Cell Research) awarded by the Landesstiftung Baden-Württemberg
Schöller-Junkmann Award of the German Endocrine Society
Travel Grant of the Endocrine Society
Marius Tausk Award of the German Endocrine Society
Emmy-Noether Grant of the German Research Council Phase I
Award for the best doctoral thesis of the medical faculty ("Unterfränkische Gedenkjahrstiftung für Wissenschaft")
MAJOR COLLABORATIONS (Selection)
Collaborations are in place with a number of ENSAT members and more specifically with the consortium of ENSAT-CANCER (Wiebke Arlt, Bruno Allolio, Martin Fassnacht, Jerôme Bertherat, Graeme Eisenhofer, Mercedes Robledo), which I coordinate since 2011. Pertaining to the proposed working program further important collaborations are in place with members of the German Conn registry (Martin Reincke, Marcus Quinkler, Holger Willenberg) and with the Helmholtz Centre in Munich for genetic investigation and mouse models (Tim Strom, Martin Hrabe de Angelis).
Authors, Title, Journal
Beuschlein F, Strasburger CJ, Siegerstetter V, Moradpour D, Lichter P, Bidlingmaier M, Blum HE, Reincke M.
Acromegaly due to growth hormone secretion by a malignant B-cell lymphoma
N Engl J Med; 2000 342(25):1871-6
Fassnacht M, Terzolo M, Allolio B, Baudin E, Haak H, Berruti A, Welin S, Schade-Brittinger C, Lacroix A, Jarzab B, Sorbye H, Torpy DJ, Stepan V, Schteingart DE, Arlt W, Kroiss M, Leboulleux S, Sperone P, Sundin A, Hermsen I, Hahner S, Willenberg HS, Tabarin A, Quinkler M, de la Fouchardière C, Schlumberger M, Mantero F, Weismann D, Beuschlein F, Gelderblom H, Wilmink H, Sender M, Edgerly M, Kenn W, Fojo T, Müller HH, Skogseid B; FIRM-ACT Study Group.
Combination chemotherapy in advanced adrenocortical carcinoma.
N Engl J Med. 2012 Jun 7;366(23):2189-97. Epub 2012 May 2.
Beuschlein F, Boulkroun S, Osswald A, Wieland T, Nielsen HN, Lichtenauer UD, Penton D, Schack VR, Amar L, Fischer E, Walther A, Tauber P, Schwarzmayr T, Diener S, Graf E, Allolio B, Samson-Couterie B, Benecke A, Quinkler M, Fallo F, Plouin PF, Mantero F, Meitinger T, Mulatero P, Jeunemaitre X, Warth R, Vilsen B, Zennaro MC, Strom TM, Reincke M.
Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension.
Nat Genet. 2013 Apr;45(4):440-4. Epub 2013 Feb 17.
Beuschlein F, Fassnacht M, Assié G, Calebiro D, Stratakis CA, Osswald A, Ronchi CL, Wieland T, Sbiera S, Faucz FR, Schaak K, Schmittfull A, Schwarzmayr T, Barreau O, Vezzosi D, Rizk-Rabin M, Zabel U, Szarek E, Salpea P, Forlino A, Vetro A, Zuffardi O, Kisker C, Diener S, Meitinger T, Lohse MJ, Reincke M, Bertherat J, Strom TM, Allolio B.
Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome.
N Engl J Med. 2014 Mar 13;370(11):1019-28. Epub 2014 Feb 26.
Beuschlein F, Weigel J, Saeger W, Kroiss M, Wild V, Daffara F, Libe R, Ardito A, Al Ghuzlan A, Quinkler M, Oßwald A, Ronchi CL, de Krijger R, Feelders RA, Waldmann J, Willenberg HS, Deutschbein T, Stell A, Reincke M, Papotti M, Baudin E, Tissier F, Haak HR, Loli P, Terzolo M, Allolio B, Müller H, Fassnacht M.
Major prognostic role of Ki67 in localized adrenocortical carcinoma after complete resection.
J Clin Endocrinol Metab. 2015 Jan 5. [Epub ahead of print]
Martin Heinrich Reincke is the director of the Medizinische Klinik and Poliklinik IV, Ludwig-Maximilians University in Munich and Chair of the Department of Endocrinology and Diabetology. The Medizinische Klinik IV is part of Ludwig-Maximilians University, the leading institution in German academic medicine.
His research specialities include adrenal physiology and pathophysiology, endocrine hypertension, pituitary disease, mineralocorticoid and glucocorticoid action and stress research. Professor Reincke is heading a research team specifically exploring the prevalence and relevance of mineralocorticoid excess in resistant hypertension on the epidemiological, clinical, genetic and molecular level.
The research teams of his clinic have particular expertise in assay development and validation for endocrine disease, development of genetically manipulated animals as models for human adrenal disease.
Professor Reincke is a member of many national and international societies, including the Endocrine Society, European Society of Endocrinology and European Network of the study of adrenal tumors. He has served in the Executive Board of the German Endocrine Society and European Society of Endocrinology, is on the editorial board of several international journals, and has served as teaching dean of the faculty from 2006-2012.
Currently, he is president of the German Endocrine Society (2014-2017). He has published more than 290 Medline listed publications cited >6000 times, his h-index is 46.
Selected 5 publications from the last 5 years (out of 298; h-index: 46)
Reincke M, Sbiera S, Hayakawa A, Theodoropoulou M, Osswald A, Beuschlein F, Meitinger T, Mizuno-Yamasaki E, Kawaguchi K, Saeki Y, Tanaka K, Wieland T, Graf E, Saeger W, Ronchi CL, Allolio B, Buchfelder M, Strom TM, Fassnacht M, Komada M. Mutations in the deubiquitinase gene USP8 cause Cushing's disease. Nat Genet. 2015 Jan;47(1):31-8.
Di Dalmazi G, Kisker C, Calebiro D, Mannelli M, Canu L, Arnaldi G, Quinkler M, Rayes N, Tabarin A, Laure Jullié M, Mantero F, Rubin B, Waldmann J, Bartsch DK, Pasquali R, Lohse M, Allolio B, Fassnacht M, Beuschlein F, Reincke M. Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study. J Clin Endocrinol Metab. 2014 Oct;99(10):E2093-100. doi: 10.1210/jc.2014-2152. Epub 2014 Jul 24.
Beuschlein F, Fassnacht M, Assié G, Calebiro D, Stratakis CA, Osswald A, Ronchi CL, Wieland T, Sbiera S, Faucz FR, Schaak K, Schmittfull A, Schwarzmayr T, Barreau O, Vezzosi D, Rizk-Rabin M, Zabel U, Szarek E, Salpea P, Forlino A, Vetro A, Zuffardi O, Kisker C, Diener S, Meitinger T, Lohse MJ, Reincke M, Bertherat J, Strom TM, Allolio B. Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome. N Engl J Med. 2014 Mar 13;370(11):1019-28.
Beuschlein F, Boulkroun S, Osswald A, Wieland T, Nielsen HN, Lichtenauer UD, Penton D, Amar L, Fischer E, Walther A, Schack V, Tauber P, Schwarzmayr T, Diener S, Allolio B, Samson-Couterie B, Benecke A, Quinkler M, Fallo F, Plouin PF, Mantero F, Meitinger T, Mulatero P, Jeunemaitre X, Warth R, Vilsen B, Zennaro MC, Strom TM, Reincke M. Somatic ATP1A1 and ATP2B3 mutations leading to aldosterone producing adenomas and secondary hypertension. Nat Genet. 2013 Apr;45(4):440-4, 444e1-2
Reincke M, Fischer E, Gerum S, Merkle K, Schulz S, Pallauf A, Quinkler M, Hanslik G, Lang K, Hahner S, Allolio B, Meisinger C, Holle R, Beuschlein F, Bidlingmaier M, Endres S; German Conn's Registry-Else Kröner-Fresenius-Hyperaldosteronism Registry Observational study mortality in treated primary aldosteronism: the German Conn's registry. Hypertension. 2012 Sep;60(3):618-24.
Graeme Eisenhofer received his PhD in 1983 from the University of Otago, New Zealand, with thesis work involving clinical research on autonomic and neuroendocrine systems. He then moved to the NIH where he carried out basic and clinical studies mapping the pathways of catecholamine metabolism. In 1988 he moved to the Baker Heart Research Institute (Melbourne, Australia), where he worked with Dr. Murray Esler on sympathetic nerve function in health and disease. He returned to the NIH in 1991 before taking up a Professorship at the University Hospital in Dresden, Germany. Together with Dr. Jacques Lenders, he developed measurements of plasma metanephrines for laboratory diagnosis of pheochromocytoma. He was also responsible for the first ever synthesis of 18F-fluorodopamine as a positron emission tomographic imaging agent for localizing catecholamine-producing tumors. At Dresden Prof. Eisenhofer heads the Division of Clinical Neurochemistry and is the Clinical Research Coordinator for the DFG-supported Dresden Adrenal Center (www.kfo252.de). Research is directed to studies of endocrine hypertension and involvement of the adrenal in pathophysiological processes. With 35 years of clinical research experience he has authored over 400 research articles, reviews and book chapters, most of which have been directed to autonomic- or adrenal-related disorders.
Institution: UNITO. Contact: email@example.com
Tasks in the project: Paolo Mulatero is with Tracy A. Williams the UNITO group leader involved in WP2 and WP4-6.
WP2 & WP4-6: His team will contribute to:
- Assessment of the omics signature for patients with secondary forms of hypertension
- Recruitment of referred hypertension patients for the multicentre screening of established omics biomarkers to identify patients with overt endocrine hypertension, with subclinical forms and patients clustering into a specific endocrine group.
- Assessment of the validity of screening for omics biomarkers in hypertension patients to establish a stratified health promotion programme in hypertensive subjects.
- Participate to the dissemination of the findings to patient organisations and to national and multinational scientific societies.
Paolo Mulatero, MD, is associate professor of internal medicine at the University of Torino, Italy; is also European specialist in clinical hypertension, member of the Endocrine Society and of the European Society of Hypertension, expert in diagnosis and therapy of secondary forms of hypertension and in particular of primary aldosteronism, PI in clinical trials and genetic studies on hypertensive patients. HI 35, IF ~ 700, i-10 index 86, total citations 5071.
- Mulatero P, Monticone S, Bertello C, Viola A, Tizzani D, Iannaccone A, Crudo V, Burrello J, Milan A, Rabbia F, Veglio F. Long-term Cardio- and Cerebro-Vascular Events in Patients with Primary Aldosteronism. J Clin Endocrinol Metab. 2013;98:4826-33.
- Mulatero P, Monticone S, Rainey WE, Veglio F, Williams TA. Role of KCNJ5 in familial and sporadic primary aldosteronism. Nat Rev Endocrinol. 2013;9:104-12.
- Mulatero P, Tauber P, Zennaro MC, Monticone S, Lang K, Beuschlein F, Fischer E, Tizzani D, Pallauf A, Viola A, Amar L, Williams TA, Strom TM, Graf E, Bandulik S, Penton D, Plouin PF, Warth R, Allolio B, Jeunemaitre X, Veglio F, Reincke M. KCNJ5 mutations in European families with nonglucocorticoid remediable familial hyperaldosteronism. Hypertension. 2012;59:235-40.
- Mulatero P, di Cella SM, Monticone S, Schiavone D, Manzo M, Mengozzi G, Rabbia F, Terzolo M, Gomez-Sanchez EP, Gomez-Sanchez CE, Veglio F. 18-hydroxycorticosterone, 18-hydroxycortisol,
- Williams TA, Mulatero P, Bidlingmaier M, Beuschlein F, Reincke M. Genetic and potential immune triggers of primary aldosteronism. Hypertension 2015;66:248-253.
-Williams TA, Monticone S, Schack VR, Stindl J, Burrello J, Buffolo F, Annaratone L, Castellano I, Beuschlein F, Reincke M, Lucatello B, Ronconi V, Fallo F, Bernini G, Maccario M, Giacchetti G, Veglio F, Warth R, Vilsen B, Mulatero P. Somatic ATP1A1, ATP2B3 and KCNJ5 mutations in aldosterone-producing adenomas. Hypertension 2014; 63: 188-195.
-Williams TA, Monticone S, Crudo V, Warth R, Veglio F and Mulatero P. VSNL1 is up-regulated in aldosterone-producing adenomas harbouring KCNJ5 mutations and protects from calcium-induced apoptosis in vitro. Hypertension 2012; 59: 833-839.
-Williams TA, Monticone S, Morello F, Liew CC, Mengozzi G, Pilon C, Asioli S, Sapino A, Veglio F, Mulatero P. Teratocarcinoma-derived growth factor-1 is upregulated in aldosterone-producing adenomas and increases aldosterone secretion and inhibits apoptosis in vitro. Hypertension 2010;55:1468-1475.
Full list of publications is available at the link
Gian Paolo RossiUNIPD
Gian Paolo Rossi, University of Padova
Professor Gian Paolo Rossi, MD, is currently working as Chair (Tenure track) of Internal Medicine, Department of Medicine-DIMED-Hypertension Unit University hospital, Padova, Professor of Medicine, Department of Medicine University of Padova, Italy, Director of The High Blood Pressure Regional Center, The Department of Medicine, University of Padova Italy, Director of the International PhD Program Arterial Hypertension Vascular Biology, University of Padova Italy. He has received his MD degree from University of Padova Magna cum laude as well as certification from Post Graduate School of Cardiology, University of Padova, Post Graduate School of Endocrinology, University of Padova. European Hypertension Specialist by European Society of Hypertension (ESH). He trained at the Dept. Heart & Hypertension Research at the Cleveland Clinic. He was visiting Scientist at German Institute for High Blood Pressure Research, Department of Pharmacology University of Heidelberg Germany, visiting Professor at Medical Academy of Gdansk Institute of Pharmacology and Toxicology Berlin and the Egyptian Society of Hypertension. He is member of European Society of Hypertension, The American College of Cardiology, The American Heart Association, The International Society of Hypertension. He has served in the Executive Board of the Italian Society of Hypertension and The European Council for Cardiovascular Research ECCR, of which is is currently the President. His scientific duties include member of the Editorial Board of The World Journal of Cardiology, The Journal of Clinical Endocrinology and Metabolism, Hypertension. He has acted as Editor in Chief of Frontiers in Cardiovascular Medicine Hypertension section. He was International expert of French INSERM and acted as external reviewer for onsite visits aimed establishing new ISERM units. Known for his leadership and coordination capabilities Prof. Rossi acts as coordinator of working group on Endothelins and Endothelial Factors of the ESH, Primary Aldosteronism of the Italian Society of Hypertension, Principal Investigator of the Genica Study, the PAPY study, the PAPPHY Study, and the Metras Study. He has published 415 papers in National and International Journals and written 20 book chapters. He has been Selected for the Harry Goldblatt Award of the AHA; has been awarded The Unindustria Treviso 2003 Awards, The 2013 Talal Zein Award of the European Society of Hypertensionand The 2013 International Award For Publication Excellence in The Journal of Clinical Endocrinology and Metabolism.
John Connell, University of Dundee
John Connell is Vice Principal and Professor of Endocrinology at the University of Dundee and the Chair of NHS Tayside.
He trained in Medicine at the University of Glasgow (graduating with commendation in 1977) and his early clinical experience was gained in the West of Scotland. He has had a long-standing interest in the regulation of adrenal corticosteroids (Aldosterone and Cortisol) and in the role of these hormones in cardiovascular disease. In particular, his work focuses on the genes that control the late stages of synthesis of aldosterone and cortisol and how variation in these genes might predispose to cardiovascular risk.
Before taking up his present role, John was Dean of the School of Medicine at the University of Dundee (2009-2012) and Head of the College of Medicine, Dentistry and Nursing, as well as Vice Principal for Research (2012-2015). During this period, he led the Medical School through a restructuring programme and a major refurbishment, to sustain its reputation among the very highest Medical Schools in the United Kingdom for the quality of its teaching, reputation of its clinical training and translational clinical science. He initiated the development of an Academic Health Sciences Partnership between the College of Medicine, Dentistry and Nursing and the NHS in Tayside that is designed to drive innovation in undergraduate and postgraduate education and training; quality improvement in healthcare and translational research. This partnership is now leading a strong portfolio of research, innovation and educational programmes.
John Connell is a Fellow of Academy of Medical Sciences, and a Fellow of the Royal Society of Edinburgh. He sits on the Finance Committee of the Academy of Medical Sciences; is Fellowship Secretary of the Royal Society of Edinburgh; Chair of the General Medical Council Education and Training Advisory Board; Chair of the Editorial Board of Clinical Endocrinology; Chair of Tenovus Tayside; and is the Vice Chair of the British Heart Foundation Programmes and Chairs Committee.
Institution: UNITO. Contact: firstname.lastname@example.org
Tasks in the project: Tracy Ann Williams is with Paolo Mulatero the UNITO group leader involved in WP2 and WP4-6.
WP2 & WP4-6: Contribution: see Paolo Mulatero
Dr. Tracy Ann Williams is a research scientist at the Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Turin, Italy. She obtained her PhD degree in Biochemistry and Molecular Biology, University of Leeds, UK and was awarded a Royal Society of Great Britain fellowship for her post-doctoral studies at the Collège de France, Paris, France. Dr. Williams subsequently moved to the University of Turin, Italy obtaining an EMBO long-term fellowship and a Marie-Curie research training grant before obtaining her current position. Her research focuses on the underlying biology of primary aldosteronism. In particular, the identification of factors or elucidation of mechanisms that trigger and sustain the aldosterone excess in this disorder.
Williams TA, Dietz SA, Theodoropoulou M, Riester A, Fischer E, Burrello J, Treitl M, Geyer L, Veglio F, Bidlingmaier M, Schopohl J, Beuschlein F, Mulatero P, Reincke M. Co-existing prolactinoma and primary aldosteronism - is there a pathophysiological link? J Clin Endocrinol Metab. 2015; in press
Williams TA, Mulatero P, Bidlingmaier M, Beuschlein F, Reincke M. Genetic and potential immune triggers of primary aldosteronism. Hypertension 2015;66:248-253.
Williams TA, Monticone S, Schack VR, Stindl J, Burrello J, Buffolo F, Annaratone L, Castellano I, Beuschlein F, Reincke M, Lucatello B, Ronconi V, Fallo F, Bernini G, Maccario M, Giacchetti G, Veglio F, Warth R, Vilsen B, Mulatero P. Somatic ATP1A1, ATP2B3 and KCNJ5 mutations in aldosterone-producing adenomas. Hypertension 2014; 63: 188-195.
Williams TA, Monticone S, Crudo V, Warth R, Veglio F and Mulatero P.
VSNL1 is up-regulated in aldosterone-producing adenomas harbouring KCNJ5 mutations and protects from calcium-induced apoptosis in vitro. Hypertension 2012; 59: 833-839.
Williams TA, Monticone S, Morello F, Liew CC, Mengozzi G, Pilon C, Asioli S, Sapino A, Veglio F, Mulatero P. Teratocarcinoma-derived growth factor-1 is upregulated in aldosterone-producing adenomas and increases aldosterone secretion and inhibits apoptosis in vitro. Hypertension 2010;55:1468-1475.
Professor Eleanor Davies, Institute of Cardiovascular and Medical Sciences, University of Glasgow .
Telephone +44 141 330 2376.
Institution: University of Glasgow
Glasgow Team: Professor Eleanor Davies (Professor of Molecular Endocrinology), Dr Marie Freel (Consultant Endocrinologist), Dr Scott MacKenzie (Lecturer), Dr John McClure (Statistician)
Tasks in the project: Eleanor Davies is co-leader of WP2 and will contribute to WP4.
The main objective of WP2 is to perform genomic analyses in a discovery cohort using multiple individual platforms. Her team will contribute to obtaining circulating miRNA profiles in patients with Primary Aldosteronism and controls. The validity of the miRNA signature will be tested in a validation cohort in WP4.
Eleanor Davies is Professor of Molecular Endocrinology at the BHF Glasgow Cardiovascular Research Institute at the University of Glasgow (UK). She received her BSc (Hons) in Biochemistry from the University of Glasgow and her PhD from the University of Edinburgh. She spent 3 years as a post-doctoral research fellow at INSERM U36 in Paris.
At Glasgow, she leads a translational research group investigating the role of the mineralocorticoid aldosterone in cardiovascular disease, focusing on the regulation of its production by the adrenal gland and its role in hypertension. Her work has been funded by grants from the MRC, BHF, CSO and Hypertension Trust. It has been published in high profile journals and has been presented at several national and international meetings. She is co-director of the University MSc Cardiovascular Sciences programme and is the Institute Post-Graduate Director.
She is a member of the Society for Endocrinology, The Endocrine Society and the American Heart Association. She is a member of council for the Society for Endocrinology and is a member of their publications and nominations committee and co-lead of the Society’s adrenal/ cardiovascular Network. She serves as a reviewer for multiple national and international funding organisations and journals. She sits on the Chief Scientist Office committee for experimental and translational medicine and is the UK lead and member of an EU-COST ADMIRE network. She has served as an Editorial board member for Endocrinology and been Chairman of the International Aldosterone conference.
Robertson S, MacKenzie SM, Alvarez-Madrazo S, Diver LA, Lin J, Stewart PM, Fraser R, Connell JM, Davies E. MicroRNA-24 is a novel regulator of aldosterone and cortisol production in the human adrenal cortex. Hypertension. 2013 Sep;62(3):572-8.
Alvarez-Madrazo S, Mackenzie SM, Davies E, Fraser R, Lee WK, Brown M, Caulfield MJ, Dominiczak AF, Farrall M, Lathrop M, Hedner T, Melander O, Munroe PB, Samani N, Stewart PM, Wahlstrand B, Webster J, Palmer CN, Padmanabhan S, Connell JM. Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension. Hypertension. 2013 Jan;61(1):232-9.
Freel EM, Mark PB, Weir RA, McQuarrie EP, Allan K, Dargie HJ, McClure JD, Jardine AG, Davies E, Connell JM. Demonstration of blood pressure-independent noninfarct myocardial fibrosis in primary aldosteronism: a cardiac magnetic resonance imaging study. Circulation Cardiovasc Imaging. 2012 (6):740-7.
McManus F, Sands W, Diver L, MacKenzie SM, Fraser R, Davies E, Connell JM. APEX1 regulation of aldosterone synthase gene transcription is disrupted by a common polymorphism in humans. Circ Res. 2012 Jul 6;111(2):212-9.
Connell JM, MacKenzie SM, Freel EM, Fraser R, Davies E. A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function. Endocr Rev. 2008 Apr;29(2):133-54.
Wiebke Arlt undertook her under- and postgraduate training in Medicine and Endocrinology at the Universities of Cologne and Würzburg, Germany. This was followed by postdoctoral training at the University of California at San Francisco, funded by the German Research Council (DFG).
After her return to Germany she joined the University of Birmingham in 2002, funded by a DFG Heisenberg Senior Fellowship. In 2004 she was awarded an MRC Senior Clinical Fellowship, followed by a personal chair in 2006 and the William Withering Chair of Medicine in 2014.
Her research has unraveled the genetic and functional basis of several monogenic disorders affecting androgen synthesis and metabolism.She leads a multi-disciplinary research comprising clinician scientists, molecular biologists, biochemists and computer scientist, focussing on the exploration of the steroid metabolome and its impact on human disease.
Wiebke has led the Centre for Endocrinology, Diabetes and Metabolism (CEDAM) since its creation in 2008 and now serves as the founding Director of the Institute of Metabolism and Systems Research (IMSR) at Birmingham. Her multiple national and international awards include the Society for Endocrinology UK Medal (2009) and Clinical Endocrinology Trust Lecture (2015), the EJE Prize (2009) and Clinical Endocrinology Trust Medal (2015) of the European Society of Endocrinology, and the Ernst Oppenheimer Award 2010 of the Endocrine Society USA.
Dr Emily Jefferson joined the University of Dundee in 2012 and is the Director of the Health Informatics Centre (HIC). Emily read Biochemistry at the University of St Andrews before moving to attain a PhD in the more computational field of Bioinformatics at the University of Dundee. After a post-doc in Bioinformatics, Emily left academia to work in the banking sector for a large software company. She was promoted to Project Director, managing the delivery and development of multi-million pound software systems to several International Banks. Emily then took a career break to solo cycle from New Zealand to the UK over 1 year.
Emily wishes to combine an understanding of biological research and academia with commercial IT Project Management and Development experience and apply these skills to the field of Health Informatics.
Emily is co-director of Farr@Dundee and also has responsibility for the overall management, technical direction and leadership for a team of software developers and data analysts within HIC.
Henri Timmers MD, PhD
Dept. of internal medicine, section of Endocrinology (471)
Radboud University Medical Centre
PO Box 9101, 6500 HB Nijmegen, The Netherlands
Tel: +31 243614599
Fax: +31 243618809
Positions: Clinical endocrinologist and steering committee member of the European Network for the Study of Adrenal Tumors www.ensat.org and the international Pheochromocytoma and Paraganglioma Research Support Organization www.pressor.org
Principal clinical and scientific focus: adrenal diseases, in particular pheochromocytoma and paraganglioma
Tasks within ENSAT-HT consortium: Participation in WP3 (metabolomic profiling by nuclear magnetic resonance spectroscopy) and WP5 (clinical trial).
Professor Richard O. Sinnott is the Director of eResearch at the University of Melbourne and Chair of Applied Computing Systems. In these roles he is responsible for all aspects of eResearch (research-oriented IT development) at the University. He has been lead software engineer/architect on an extensive portfolio of national and international projects, with specific focus on those research domains requiring finer-grained access control (security). Within ENSAT-HT Richard is the technical lead for WP1 and providing the underlying data systems and security-oriented IT infrastructure. This leverages the existing ENSAT-CANCER systems developed by Richard’s team (now used globally by - at present - 76 cancer centres).
Richard was formerly the Technical Director of the UK National e-Science Centre; Director of e-Science at the University of Glasgow; Deputy Director (Technical) for the Bioinformatics Research Centre also at the University of Glasgow, and for a while the Technical Director of the National Centre for e-Social Science. He has a PhD in Computing Science; an MSc in Software Engineering and a BSc in Theoretical Physics. He has over 250 peer-reviewed publications across a range of computing and application-specific domains.
- Därr, C. Pamporak, M. Peitzsch, K. Miehle, A. Prejbisz, D. Weismann, F. Beuschlein, R.O. Sinnott, S. Bornstein, H. Neumann, A. Januszewicz, J. Lenders, G. Eisenhofer, Biochemical diagnosis of phaeochromocytoma using plasma free normetanephrine, metanephrine and methoxytyramine: Importance of supine sampling under fasting conditions, Journal of Clinical Endocrinology, 2013, doi: 10.1111/cen.12327.
- Penno, J. Couper, M. Craig, P. Colman, W. Rawlinson, A. Cotterill, T. Jones, L. Harrison, P. Baghurst, S. Barry, F. Cameron, J. Dodd, C. Duran, J. Forbes, M. Makrides, G. Morahan, K. Nelson, A. Nankervis, R.O. Sinnott, J. Wentworth, Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes, BMC Pediatrics, 13:124, doi:10.1186/1471-2431-13-124.
- Kolesinska, S.F. Ahmed, M. Niedziela, J. Bryce, M. Rodie, J. Jiang, R.O. Sinnott, I. Hughes, F. Darendeliler, O. Hiort, Y. van der Zwan, M. Cools, T. Guran, P.M. Holterhus, S. Bertelloni, L. Lisa, W. Arlt, N. Krone, M. Ellaithi, A. Balsamo, I. Mazen, A. Nordenstrom, K. Lachlan, M. Alkhawari, P. Chatelain, N. Weintrob, Changes Over Time In Sex Assignment For Disorders Of Sex Development, Journal of Paediatrics, May 2014.
- Kanwal, A. Lonie, R.O. Sinnott, C. Anderson, Challenges of Large-scale Biomedical Workflows on the Cloud – A Case Study on the Need for Reproducibility of Results, 28th IEEE International Conference on Computer Based Medical Systems, Sao Paolo, Brazil, June 2015.
- Wise, C. Friedrich, S. Nepal, S. Chen, R.O. Sinnott, CloudDocs: Secure Scalable Document Sharing on Public Clouds, IEEE Cloud Conference 2015, New York, USA, July 2015.
Prof. Richard O. Sinnott
322 Doug McDonell Building, University of Melbourne
Tel: +61-(0)3-9035-4531 Fax: -8700 Mob: +61-(0)435-964-844
Dr Jaap Deinum, MD PhD (b. 1961)
1979-1980 Liberal arts propaedeutics at Free Academy, Driebergen, NL
- Medical School of Erasmus University, Rotterdam, Netherlands
- Social service (conscientious objector to military service), Univ. Hospital Dijkzigt (now: Erasmus MC) Rotterdam, NL
- Training as an internist Univ. Hospital Dijkzigt Rotterdam, supervisor Prof. Dr M.A.D.H. Schalekamp
1994 - Postdoc at INSERM U. 367, Paris, head Dr. F. Alhenc-Gelas
1995-2002 - Member of staff, department of Medicine, Erasmus Medical Center Rotterdam
1999 - PhD thesis ‘Structure and regulation of prorenin’
2002-now - Senior staff member, department of Medicine, University Medical Center Nijmegen St. Radboud
2003 - registration as Specialist in Vascular Medicine and as European Hypertension Specialist, associate professor
2012 - head of ESH Hypertension Excellence Center Radboud UMC
-Member of European Society of Hypertension and European Council for cardiovascular research and various national and international associations in the fields of hypertension, vascular medicine/biology, endocrinology, and nephrology. Co-founder of the 'Internistisch Vasculair Genootschap’, Current president of the Dutch Society of Hypertension.
-Research interests: -genetics of hypertension, genomic screens, genetic determinants of sodium transport in renal tubules
-treatment strategies in primary hypertension
-diagnostic strategies in secondary hypertension, in particular endocrine hypertension
Joyce Koffeman, MSc.
Dept. of Internal Medicine, section of Vascular Medicine and Endocrinology (481)
Radboud University Medical Centre
PO Box 9101, 6500 HB Nijmegen, The Netherlands
Tel: +31 243618819
Fax: +31 243635126
Positions: 9 years experience in Clinical trials as CRA, Senior Study Nurse and Research Coordinator, within Radboud University Medical Centre as well as the pharmacy. Conducting and coordinating clinical trials according to ICH-GCP guidelines and (European) laws and regulations. Phase I, II, II and IV in different areas: geriatrics, HIV, Food supplements, hypertension, MS, surgery, oncology, malaria, drug eluting stents, allergology and cannabinoids.
Tasks within ENSAT-HT consortium: coordinating role for Radboud University Medical Centre for WP3, WP4 and WP5.
Anthony Stell, Clinical Informatics Developer
University of Melbourne
Anthony Stell is a clinical informatics developer in the eResearch group at the University of Melbourne. In this role he is responsible for the project management and technical development of several advanced registries supporting clinical research in various domains such as adrenal cancer, spinal trauma and traumatic brain injury. He is the senior software developer for the ENSAT registry, which is a unique, well-used (with 76 active centers), security-focused resource for adrenal cancer, with advanced features to support statistical and bio-banking analyses for a diverse set of studies. Within ENSAT-HT Anthony is the senior technical developer for WP1 and will provide technical support and assistance for the underlying IT infrastructure.
Anthony worked formerly as a Grid Engineer at the UK National e-Science Centre at the University of Glasgow where he developed distributed, real-time clinical systems to support brain-injury studies in Europe (the Avert-IT project) and epidemiological trials in the UK (the VOTES project). During this time he also served as a member of the Grid Engineering Task Force (Grid ETF, UK).
He is currently in the final year of a PhD in Clinical Physics at the University of Glasgow studying clinical variation and guideline adherence in traumatic brain injury through neurological ICU data analysis. He has an MSc in Information Technology from the University of Glasgow, an MPhys in Astrophysics from the University of Edinburgh, and is a Chartered Member of the British Computing Society (CITP MBCS). He has over 40 peer-reviewed publications across a range of computing and application-specific domains.
- Eisenhofer G, Brown S, Peitzsch M, Pelzel D, Lattke P, Glöckner S, Stell A, Prejbisz A, Fassnacht M, Beuschlein F, Januszewicz A, Siegert G, Reichmann H - "Levodopa therapy in Parkinson’s disease: influence on liquid chromatographic tandem mass spectrometric-based measurements of plasma and urinary normetanephrine, metanephrine and methoxytyramine", Annals of Clinical Biochemistry, 2014 Jan; 51 (Pt 1):38-46
- Felix Beuschlein, Jens Weigel, Wolfgang Saeger, Matthias Kroiss, Vanessa Wild, Fulvia Daffara, Rosella Libé, Arianna Ardito, Abir Al Ghuzlan, Marcus Quinkler, Andrea Oßwald, Cristina L. Ronchi, Ronald de Krijger, Richard A. Feelders, Jens Waldmann, Holger S. Willenberg, Timo Deutschbein, Anthony Stell, Martin Reincke, Mauro Papotti, Eric Baudin, Frédérique Tissier, Harm R. Haak, Paola Loli, Massimo Terzolo, Bruno Allolio, Hans-Helge Müller, and Martin Fassnacht - "Major Prognostic Role of Ki67 in Localized Adrenocortical Carcinoma After Complete Resection", The Journal of Clinical Endocrinology & Metabolism 2015, 100:3, 841-849
- Anthony Stell, Richard Sinnott, Jipu Jiang, Rob Donald, Iain Chambers, Giuseppe Citerio, Per Enblad, Barbara Gregson, Tim Howells, Karl Kiening, Pelle Nilsson, Arminas Ragauskas, Juan Sahuquillo, Ian Piper – “Federating distributed clinical data for the prediction of adverse hypotensive events”, Philosophical Transactions of the Royal Society of London A, 2009, vol 367 (1898), pp 2679-2690
Clinical Informatics Developer
324 Doug McDonell Building, University of Melbourne
Tel: +61-(0)3-9035-3755 Mob: +61-(0)478-313-748
Catherine joined Inserm-Transfert in 2005. She graduated from the Ecole Normal Superieure, Catherine received a Ph.D. in Molecular Virology at the University René Diderot in 1996. She completed her studies mainly in the private sector (pre-doctoral study at Loreal and PhD thesis at Genset). After her thesis, she continued her research on cardiovascular disease in biotechnology companies. She also won the Aventis Foundation for the creation of the company Helios Biosciences and helped set up within the engineering school ESIEA a teaching methodology in bioinformatics and life sciences. She is a regular expert at the European Commission for the People program. Thanks to her job training and experience as project leader in biotech, Catherine has experience with managing international research projects and multidisciplinary. She is fluently bilingual through daily practice of English in their professional activities.
As senior manager of the European project, Catherine Clusel acquired within 7 years of Inserm-Transfert extensive experience installing and managing European projects (FP6 and FP7) and transatlantic (Fondation Leducq) in the field of metabolic and cardiovascular diseases. She participated in the assembly and / or management projects such as: EVGN (FP6-NoE coordinated by Inserm), Florinash (FP7-medium-scale coordinated by INSERM) and MetaCARDIS (FP7-wide scale coordinated by INSERM). Catherine has a unique experience on the installation and management of transatlantic alliances Foundation Leducq (CAPTAA; cycAMP, MITRAL).
Silvia Monticone earned her MD in 2007 from University of Torino (Italy) and in 2013 she completed a residency in Internal Medicine at the same university.
In 2011, she spent one year as research fellow at Georgia Health Sciences University in the Department of Physiology, where she started a successful collaboration with the laboratory directed by Prof. WE Rainey. She is currently research scientist in Internal Medicine at the University of Torino, Italy; she is also member of the Italian Society of Hypertension since 2008 and in 2012 she won the Italian Hypertension Society fellowship.
- Monticone S, Satoh F, Giacchetti G, Viola A, Morimoto R, Kudo M, Iwakura Y, Ono Y, Turchi F, Paci E, Veglio F, Boscaro M, Rainey W, Ito S, Mulatero P. Effect of adrenocorticotropic hormone stimulation during adrenal vein sampling in primary aldosteronism. Hypertension. 2012;59:840-6.
- Monticone S, Hattangady NG, Nishimoto K, Mantero F, Rubin B, Cicala MV, Pezzani R, Auchus RJ, Ghayee HK, Shibata H, Kurihara I, Williams TA, Giri JG, Bollag RJ, Edwards MA, Isales CM, Rainey WE. Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells. J Clin Endocrinol Metab. 2012;97:E1567-72.
- Monticone S, Hattangady NG, Penton D, Isales CM, Edwards MA, Williams TA, Sterner C, Warth R, Mulatero P, Rainey WE. A Novel Y152C KCNJ5 Mutation Responsible for Familial Hyperaldosteronism Type III. J Clin Endocrinol Metab. 2013;98:E1861-5.
- Monticone S, Satoh F, Viola A, Fischer E, Vonend O, Bernini G, Lucatello B, Quinkler M, Ronconi V, Morimoto R, Kudo M, Degenhart C, Gao X, Carrara D, Willenberg HS, Rossato D, Mengozzi G, Riester A, Paci E, Iwakura Y, Burrello J, Maccario M, Giacchetti G, Veglio F, Ito S, Reincke M, Mulatero P. Aldosterone Suppression on Contralateral Adrenal During Adrenal Vein Sampling does not Predict Blood Pressure Response After Adrenalectomy. J Clin Endocrinol Metab. 2014;99: 4158-66.
- Monticone S, Viola A, Rossato D, Veglio F, Reincke M, Gomez-Sanchez C, Mulatero P. Adrenal vein sampling in primary aldosteronism: towards a standardised protocol. Lancet Diabetes Endocrinol. 2015;3:296-303.
Full list of publications is available at the link http://www.ncbi.nlm.nih.gov/pubmed/?term=monticone+s
Tasks in the project: Franco Rabbia is participant from the UNITO group involved in WP4-5.
WP4-5: Contribution: - Recruitment of referred hypertension patients for the multicentre screening of established omics biomarkers to identify patients with overt endocrine hypertension, with subclinical forms and patients clustering into a specific endocrine group.
- Assessment of the validity of screening for omics biomarkers in hypertension patients to establish a stratified health promotion programme in hypertensive subjects.
MD 25/11/1960 Turin
Graduation in Medicine and surgery (1986)
Clinical Fellow in Internal Medicine University of Turin( 1987-1992) (prof L. Chiandussi),)
From 1989 to 2002 senior house officier Division of Internal Medicine, Hypertension Unit (Director Prof. L. Chiandussi). From 2003 to now senior Registrar Division of Internal Medicine, Hypertension Unit (Director Prof. F. Veglio) Azienda. Ospedaliera Città della Salute e della Scienza- University of Turin.
Awards and Honors: European Society of Hypertension Specialist since 2001
Member: European Society of Hypertension, Italian Society of Hypertension
Teacher: degree course of Dietician University of Turin
Referee: BMJ, Preventive Medicine, Pediatrics, Circulation, International journal of Obesity
- Covella M, Milan A, Totaro S, Cuspidi C, Re A, Rabbia F, Veglio F. Echocardiographic aortic root dilatation in hypertensive patients: a systematic review and meta-analysis. J Hypertens. 2014;32:1928-35
-Totaro S, Rabbia F, Testa E, Covella M, Berra E, Fulcheri C, Mulatero P, Veglio F. Appropriateness of referral to a European society of hypertension center of excellence. J Clin Hypertens (Greenwich). 2012;14:729-30.
-Rabbia F, Rabbone I, Totaro S, Testa E, Covella M, Berra E, Bertello MC, Gioia E, Cerutti F, Veglio F. Evaluation of blood pressure/height ratio as an index to simplify diagnostic criteria of hypertension in Caucasian adolescents. J Hum Hypertens. 2011;25:623-4.
-Veglio F, Paglieri C, Rabbia F, Bisbocci D, Bergui M, Cerrato P. Hypertension and cerebrovascular damage. Atherosclerosis. 2009;205:331-41.
-Leotta G, Rabbia F, Canadè A, Testa E, Papotti G, Mulatero P, Veglio F. Characteristics of the patients referred to a Hypertension Unit between 1989 and 2003. J Hum Hypertens. 2008;22:119-21
Institution: UNITO. Contact: email@example.com
Tasks in the project: Franco Veglio is participant from the UNITO group involved in WP4-5.
WP4-5: Contribution: see Franco Rabbia
Biography: Franco Veglio, MD, is Full Professor of Internal Medicine at the University of Turin, Italy, Head of Medical Sciences Department; Director of Internal Medicine and Hypertension Division; European Specialist in Clinical Hypertension, member of the European Society of Hypertension.. Main research topics:clinical studies on essential and endocrine hypertension; physiopathological studies on in the mechanism of resistant arterial hypertension. HI 41, IF ~ 950, i-10 index 126, total citations 6322
-Covella M, Milan A, Totaro S, Cuspidi C, Re A, Rabbia F, Veglio F. Echocardiographic aortic root dilatation in hypertensive patients: a systematic review and meta-analysis. J Hypertens. 2014; 32:1928-35
-Milan A, Puglisi E, Ferrari L, Bruno G, Losano I, Veglio F. Arterial hypertension and cancer. Int J Cancer. 2014;134:2269-77
-Milan A, Avenatti E, Tosello F, Iannaccone A, Leone D, Magnino C, Veglio F. Aortic root dilatation in essential hypertension: prevalence according to new reference values. J Hypertens. 2013;31:1189-95.
- Veglio F, Puglisi E, Milan A, Mulatero P. Combinations of renin-angiotensin-aldosterone system antagonists: true advantages? Curr Pharm Des. 2012;18:952-7.
-Grosso A, Cheung N, Veglio F, Wong TY. Similarities and differences in early retinal phenotypes in hypertension and diabetes. J Hypertens. 2011;29:1667-75
Institution: UNITO. Contact: firstname.lastname@example.org
Tasks in the project: Jacopo Burrello is participant from the UNITO group involved in WP4-5.
WP4-5: Contribution: see Franco Rabbia
Jacopo Burrello, MD, is research fellow at the Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Turin, Italy. He is also member of the Italian Society of Hypertension.
- Mulatero P, Monticone S, Bertello C, Viola A, Tizzani D, Iannaccone D, Crudo V, Burrello J, Milan A, Rabbia F, Veglio F. Long-Term Cardio- and Cerebrovascular Events in Patients With Primary Aldosteronism. J Clin Endocrinol Metab 2013; 98: 4826-4833.
- Williams TA, Monticone S, Vivien R, Burrello J, Buffolo F, Castellano I, Beuschlein F, Reincke M, Lucatello B, Fallo F, Maccario M, Veglio F, Mulatero P, et al. Somatic ATP1A1, ATP2B3, and KCNJ5 Mutations in Aldosterone-Producing Adenomas. Hypertension 2013; 63(1):188-195.
- Monticone S, Satoh F, Viola A, Lucatello B, Burrello J, Maccario M, Veglio F, Reincke M, Mulatero P et al. Aldosterone Suppression on Contralateral Adrenal During Adrenal Vein Sampling does not Predict Blood Pressure Response After Adrenalectomy. J Clin Endocrinol Metab 2014; 99(11):4158-66.
- Grillo A, Bernardi S, Rebellato A, Fabris B, Bardelli M, Burrello J, Rabbia F, Veglio F, Fallo F, Carretta R. Ambulatory Blood Pressure Monitoring-Derived Short-Term Blood Pressure Variability in Primary Aldosteronism. J of Clin Hyperten 2015; (Epub ahead of print).
- Williams TA, Dietz A, Theodoropoulou M, Riester A, Fischer E, Burrello J, Treitl M, Geyer L, Veglio F, Bidlingmaier M, Schopohl J, Beuschlein F, Mulatero P, Reincke M. Co-existing prolactinoma and primary aldosteronism - is there a pathophysiological link? J Clin Endocrinol Metab 2015; (Epub ahead of print);
Full list of publications is available at the link
ENSAT-HT wins awardWe are very proud to announce that ENSAT-HT has received the French Award “Etoiles de l’Europe”! This award is organised annually in order to valorise the French coordination of...
ENS@T-HT partners submitted a new patent application to develop a multi-omics signature and use of identified biomarkers to detect endocrine types of hypertension, different from primary hypertension.Paris, 17 May 2021 Public statement ENS@T-HT partners submitted a new patent application to develop a multi-omics signature and use of identified biomarkers to detect endocrine types...
ENSAT-HT ExCom meeting November 2019The most recent ENSAT-HT Executive Commitee meeting took place on 8th of November 2019 in Rotterdam.
ENSAT-HT first Results !ENSAT-HT consortium meeting 2019 First results for biomakers from machine learning have been presented at the ENSAT-HT consortium in Lyon, France on 16th May 2019 by our partner...