Ens@t-HT is an EU funded Horizon 2020 research and innovation project that will investigate hypertension and whether it is possible to develop more personalised approaches to treatment and disease management.

The project comprises of a number of work packages that will focus on specific aspects and tasks. You can get an overview and the context of the project here. Below you can find out more about each work package and how they relate to each other.


Work package 1: Bioinformatic modelling and data management

This work package will provide the expertise and the computing infrastructure required to support all aspects of the ens@t-ht project. This includes support for seamless, security-oriented linkage with the ENS@T-CANCER patient data registries and a variety of other data orientated tasks.

Work package 2: Genomics and genetics

The main objective of work package 2 is to provide genomics data from multiple individual platforms. Together with data flowing from work package 3, this compiled and integrated dataset will be the basis of multidimensional bioinformatic modelling and identification of molecular signatures in work package 1, to be subsequently used as omics-based circulating biomarkers in work package 4.

Work package 3: Identification and validation of metabolomics-derived biomarkers

The main objective of work package 3 is to identify metabolite signatures specific for different forms of endocrine hypertension with further exploration for stratifying patients with essential hypertension.

Work package 4: Clinical studies

The main objective of work package 4 is to assess the validity and usefulness of omics signatures identified and validated in work packages 1, 2 and 3 for improved identification and risk stratification of patients with EHBP and stratification of patients with PHT.

Work package 5: Assessment and validation of the approach for stratified health promotion

The main objective of this work package is 1) to identify a method to assess the potential medical, social, economic and ethical impact of a risk stratification for patients with endocrine hypertension and 2) to test it with the trial run in work package 4.

Work package 6: Dissemination, exploitation and IP management

The dissemination activities of the project will ensure international visibility and acknowledgment of the ens@t-ht project. This WP will ensure the optimal exploitation of the results of ens@t-ht.

Work package 7: Management

The management tasks of the project will be completed in this work package. Tasks will focus on strategic objectives and issues, managerial tasks and administration.


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People

Scientific Coordinator: Dr Maria -Christina Zennaro, Head of INSERM U970 team 14: Genetic mechanisms of aldosterone-related disorders. maria-christina.zennaro@inserm.fr

Project Manager (INSERM-Transfert): Catherine Clusel catherine.clusel@inserm-transfert.fr

Project Manager (INSERM-Transfert): Kristina Fiedler kristina.fiedler@inserm-transfert.fr

More contact details here

Places

Paris Cardiovascular Research Center (PARCC), European Georges Pompidou Hospital, 56 rue Leblanc, 75015 Paris, France

INSERM-Transfert, Paris Biopark, 7 rue Watt, 75013 Paris, France

Maps

European Georges Pompidou Hospital


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INSERM-Transfert


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